PANS rarely acts alone. Below are the seven most common PANS co-infections and overlapping syndromes. Doctors need to also treat all co-infections to prevent episodes.
Kleine-Levin Syndrome
Commonly known as “Sleeping Beauty,” syndrome, Kleine-Levin syndrome is a neurological disorder where the patient excessively sleeps. Other symptoms include excessive eating, hypersexuality in boys, and depression in girls.
Ehlers-Danlos Syndrome
A group of thirteen disorders affecting connective tissues. The primary type to consider is the least severe hypermobility. Hypermobility in children leads to weak muscle tone, which can delay motor skills development and cause loose joints that are painful and easily dislocated.
Arnold-Chiari Malformation
Structural defects at the base of the skull. In most people, parts of the brainstem and cerebellum reside above an opening in the head. Arnold-Chiari malformation, a part of the cerebellum, extends below the opening into the upper spinal canal, causing a spinal fluid blockage.
Mast Cell Activation Disorder
The innate immunity is the body’s rapid, immediate, and non-specific response to foreign invaders. Mast cells are a vital player in the innate immune response. The body’s first line of defense is the mast cells. Mast cells patrol your mucous membranes, skin, and connective tissue. Mast cell activation disorder (MCAD) causes an excessive release of chemical mediators from the cells.
“POTS and PANS”
Postural orthostatic tachycardia syndrome (POTS) is a condition that causes an abnormal increase in the heart rate when a person stands from a prone position, lying down.
NeuroBorreliosis
A neurological manifestation of Lyme disease. It is caused by spirochetes affecting the brain and central nervous system.
NeuroBorreliosis is a significant trigger for PANS. Over 70% of my patient population have Stage 3 Borreliosis and PANS. If CIRS is also positive, it becomes a very complex puzzle of dysregulated immune responses.
Late Stage Lyme Autoimmunity
Long-term exposure of the immune system to spirochetes and/or borrelial compounds of Lyme disease may induce a chronic autoimmune disease.
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